Do aluminum radiators require special coolant? Can you mix Dexcool with Prestone Antifreeze? Perfectly OK. The new Prestone bright yellow coolant is compatible with any coolant used by any car brand or manufacturer. It says so right on the label. I have 2 gallons of the stuff, mixed 50/50 with distilled water. 292 posts · Joined 2011. #1 · Nov 27, 2018. I've heard of these zinc anodes you can drop in your radiator, attached to a radiator cap or you can get one of that is attached to the drain plug. Any acids that form in the coolant are supposed to attack this zinc before it attacks the copper or aluminum core. That's the theory anyway. In my dragster 302 chevy, My block was filled for stability, and I did not run any coolant. alcohol was the fuel. I cranked it in the pits to get some heat in the eng, and was towed to the line,started eng, burnout, run, then made the turn off and found a out of the way to park, shut it down. . 48fordnut, Nov 22, 2010. sFAaC.